Dr. Samuel Suárez-Pantiga, Cristina Hernández-Díaz, Dr. Eduardo Rubio and Prof. Dr. José M. González Intermolecular [2+2] Reaction of N-Allenylsulfonamides with Vinylarenes: Enantioselective Gold(I)-Catalyzed Synthesis of Cyclobutane Derivatives Angewandte Chemie International Edition 51
Golden touch: N-allenylsulfonamides react with styrene derivatives to furnish chiral cyclobutanes in both high yield and enantioselectivity at −70 °C. Phosphoramidite ligands such as 1, facilitate this asymmetric gold(I)-catalyzed [2+2] cycloaddition. Tf=trifluoromethanesulfonyl.
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