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Dr. Thorsten Stafforst and Marius F. Schneider An RNA–Deaminase Conjugate Selectively Repairs Point Mutations Angewandte Chemie International Edition 51

Version of Record online: 4 OCT 2012 | DOI: 10.1002/anie.201206489

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Checking for mistakes: By conjugating a catalytic domain with a guide RNA, deamination activity can be harnessed to repair a specific codon on mRNA. This method can be used for the highly selective repair of point mutations in mRNA by site-selective editing.

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