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Dr. Vittorio Limongelli, Stefano De Tito, Dr. Linda Cerofolini, Dr. Marco Fragai, Dr. Bruno Pagano, Dr. Roberta Trotta, Dr. Sandro Cosconati, Dr. Luciana Marinelli, Prof. Ettore Novellino, Prof. Ivano Bertini, Prof. Antonio Randazzo, Prof. Claudio Luchinat and Prof. Michele Parrinello The G-Triplex DNA Angewandte Chemie International Edition 52

Article first published online: 17 JAN 2013 | DOI: 10.1002/anie.201206522

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Triplex with a twist: Through metadynamics calculations, the thrombin binding aptamer (TBA) has been shown to adopt a stable G-triplex structural motif, in addition to the usual G-quadruplex (see scheme). An 11-mer oligonucleotide was also shown to form a stable G-triplex, whose structural and thermodynamic properties have been characterized.

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