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Dr. Zhe-Ming Wang and Prof. Dr. Hilal A. Lashuel Discovery of a Novel Aggregation Domain in the Huntingtin Protein: Implications for the Mechanisms of Htt Aggregation and Toxicity Angewandte Chemie International Edition 52

Version of Record online: 12 NOV 2012 | DOI: 10.1002/anie.201206561

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Aggravating aggregation: An N-terminal domain that is in close proximity to the polyQ domain in the huntingtin protein, htt105–138, is shown to be highly aggregation prone (see scheme). Potential cross-talk between this domain and the polyQ region may play a central role in regulating the aggregation and toxicity of Htt-N-terminal fragments.

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