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Dr. Min Suk Shim, Dr. Suk Ho Bhang, Dr. Kyunghwan Yoon, Prof. Kyunghee Choi and Prof. Younan Xia A Bioreducible Polymer for Efficient Delivery of Fas-Silencing siRNA into Stem Cell Spheroids and Enhanced Therapeutic Angiogenesis Angewandte Chemie International Edition 51

Article first published online: 16 OCT 2012 | DOI: 10.1002/anie.201206595

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Larger is better: Fas-silencing siRNA can be delivered into the cytoplasm of human mesenchymal stem cells (hMSCs) by a bioreducible polymer (see picture). The enhanced anti-apoptotic activity of the Fas-silenced hMSCs means that they can be readily formulated as enlarged spheroids to significantly enhance angiogenic efficacy as compared to their smaller counterparts.

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