Dipl.-Chem. Jens Willwacher, Dr. Nina Kausch-Busies and Prof. Alois Fürstner Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide Angewandte Chemie International Edition 51
Subtle but distinctive: The stereostructure of the biologically highly promising antimitotic agent leiodermatolide was uncertain. A short, efficient, and flexible total synthesis based on ring-closing alkyne metathesis as the key step has now solved the puzzle. Subtle differences in the 1H NMR spectra of the structure shown and the conceivable isomer proved invaluable for the assignment.
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