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Conor J. Pierce, Mary Nguyen and Prof. Catharine H. Larsen Copper/Titanium Catalysis Forms Fully Substituted Carbon Centers from the Direct Coupling of Acyclic Ketones, Amines, and Alkynes Angewandte Chemie International Edition 51

Version of Record online: 26 OCT 2012 | DOI: 10.1002/anie.201206674

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Three-component coupling, with a pair: The combination of CuII and TiIV catalyzes the first three-component coupling of unactivated ketones with a diverse range of amines and terminal alkynes. Tetrasubstituted propargylamines are formed under green, solvent-free conditions (see scheme). This dual metal system overcomes the barrier to ketimine formation and subsequent attack, opening a new path to multicomponent reactions of ketone electrophiles.

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