Dr. Jungwoon Lee, Yan Xia, Mi-Young Son, Guanghai Jin, Binna Seol, Min-Jeong Kim, Dr. Myung Jin Son, Misol Do, Minho Lee, Prof. Dongsup Kim, Prof. Kyeong Lee and Dr. Yee Sook Cho A Novel Small Molecule Facilitates the Reprogramming of Human Somatic Cells into a Pluripotent State and Supports the Maintenance of an Undifferentiated State of Human Pluripotent Stem Cells Angewandte Chemie International Edition 51
Version of Record online: 4 NOV 2012 | DOI: 10.1002/anie.201206691
Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
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