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Markus Ochs, Dr. Susana Carregal-Romero, Dr. Joanna Rejman, Prof. Kevin Braeckmans, Prof. Stefaan C. De Smedt and Prof. Wolfgang J. Parak Light-Addressable Capsules as Caged Compound Matrix for Controlled Triggering of Cytosolic Reactions Angewandte Chemie International Edition 52

Article first published online: 14 NOV 2012 | DOI: 10.1002/anie.201206696

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Release me: Polyelectrolyte capsules with different cargo in their cavities and plasmonic and magnetic nanoparticles in their walls were synthesized. Enzymatic reactions were triggered inside cells by light-mediated opening of two individual capsules containing either an enzyme or its substrate, by using photothermal heating. Furthermore, this technique allows controlled release of mRNA from capsules, thereby resulting in synthesis of green fluorescent protein (GFP).

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