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Naoki Matsuda, Dr. Koji Hirano, Prof. Dr. Tetsuya Satoh and Prof. Dr. Masahiro Miura Copper-Catalyzed Amination of Ketene Silyl Acetals with Hydroxylamines: Electrophilic Amination Approach to α-Amino Acids Angewandte Chemie International Edition 51

Article first published online: 15 OCT 2012 | DOI: 10.1002/anie.201206755

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Role reversal: The title reaction has been developed to deliver α-amino acids under very mild reaction conditions (see scheme; dpppen=1,5-bis(diphenylphosphino)pentane). The catalysis provides a new C[BOND]N bond-forming approach for the synthesis of α-amino acids by using an umpolung, electrophilic amination strategy.

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