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Dr. Alberto Rodríguez-Pulido, Alina I. Kondrachuk, Dr. Deepak K. Prusty, Jia Gao, Prof. Dr. Maria A. Loi and Prof. Dr. Andreas Herrmann Light-Triggered Sequence-Specific Cargo Release from DNA Block Copolymer–Lipid Vesicles Angewandte Chemie International Edition 52

Article first published online: 26 OCT 2012 | DOI: 10.1002/anie.201206783

Thumbnail image of graphical abstract

Vesicle buster: Versatile functionalized nanocontainers, based on the stable incorporation of 22 mer DNA-b-PPO block copolymers (DBCs) into lipid vesicles, are presented (see picture). The study shows effective and sequence-specific cargo release from the DBC–lipid vesicles. Hybridization of these vesicles with an oligonucleotide photosensitizer allows for singlet oxygen generation upon irradiation, which induces cargo release.

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