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Neelanjan Bose, Dr. Akira Ogawa, Dr. Stephan H. von Reuss, Joshua J. Yim, Dr. Erik J. Ragsdale, Prof. Ralf J. Sommer and Prof. Frank C. Schroeder Complex Small-Molecule Architectures Regulate Phenotypic Plasticity in a Nematode Angewandte Chemie International Edition 51

Version of Record online: 19 NOV 2012 | DOI: 10.1002/anie.201206797

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Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-based nucleoside (see scheme). These compounds act as signaling molecules to control adult phenotypic plasticity and dauer development and provide examples of modular generation of structural diversity in metazoans.

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