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Dr. Lirui Guan and Prof. Dr. Matthew D. Disney Small-Molecule-Mediated Cleavage of RNA in Living Cells Angewandte Chemie International Edition 52

Article first published online: 20 DEC 2012 | DOI: 10.1002/anie.201206888

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Killing the message: An approach to direct the cleavage of RNA targets with small molecules in living cells is described (see scheme). A bifunctional small molecule (purple) that recognizes a specific three nucleotide repeat sequence and cleaves that sequence in response to light was shown to be effective at degrading the myotonic dystrophy type 1 (DM1) extended repeat RNAs, thereby affecting biological functions.

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