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Jaganathan Karthikeyan, Radhakrishnan Haridharan and Prof. Dr. Chien-Hong Cheng Rhodium(III)-Catalyzed Oxidative C[BOND]H Coupling of N-Methoxybenzamides with Aryl Boronic Acids: One-Pot Synthesis of Phenanthridinones Angewandte Chemie International Edition 51

Version of Record online: 26 OCT 2012 | DOI: 10.1002/anie.201206890

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General solution: An efficient rhodium-catalyzed dual C[BOND]H bond activation and cyclization of N-methoxybenzamides 1 with aryl boronic acids 2 (see scheme; Cp*=Me5C5) provides a straightforward and general approach to the phenanthridinone structure, which occurs widely in natural products and drugs. Highly regioselective C[BOND]C and C[BOND]N bond formation under mild conditions afforded a wide range of substituted phenanthridinones 3.

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