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Dr. Kengo Akagawa and Prof. Dr. Kazuaki Kudo Construction of an All-Carbon Quaternary Stereocenter by the Peptide-Catalyzed Asymmetric Michael Addition of Nitromethane to β-Disubstituted α,β-Unsaturated Aldehydes Angewandte Chemie International Edition 51

Article first published online: 9 NOV 2012 | DOI: 10.1002/anie.201206916

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Pepping up Michael: An asymmetric Michael addition of nitromethane to β-disubstituted α,β-unsaturated aldehydes was realized by a resin-supported peptide catalyst. Whereas the use of a low-molecular-weight catalyst resulted in poor yields, the peptide effectively promoted the reaction in aqueous media with high enantioselectivity.

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