E-mail a Wiley Online Library Link

Dr. Kohei Fuchibe, Masaki Takahashi and Prof. Junji Ichikawa Substitution of Two Fluorine Atoms in a Trifluoromethyl Group: Regioselective Synthesis of 3-Fluoropyrazoles Angewandte Chemie International Edition 51

Version of Record online: 19 OCT 2012 | DOI: 10.1002/anie.201206946

Thumbnail image of graphical abstract

Replacing the fluorine: 3-Fluorinated pyrazoles were regioselectively synthesized by sequential substitution reactions of 2-trifluoromethyl-1-alkenes (see scheme). SN2′-type reactions of 2-trifluoromethyl-1-alkenes with deprotonated tert-butoxylcarbonyl- or arylhydrazines afforded 1,1-difluoro-1-alkenes, which were tosylated and then treated with NaH to give the desired 3-fluoropyrazoles.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field