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Haejin Kim, Wontaeck Lim, Donghong Im, Dong-gil Kim and Prof. Young Ho Rhee Synthetic Strategy for Cyclic Amines: A Stereodefined Cyclic N,O-Acetal as a Stereocontrol and Diversity-Generating Element Angewandte Chemie International Edition 51

Article first published online: 25 OCT 2012 | DOI: 10.1002/anie.201206967

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In control: A new synthetic strategy towards cyclic amines was developed and exploits a stereodefined cyclic N,O-acetal as the key stereocontrol and diversity-generating element. The cyclic N,O-acetal was prepared from the sequential asymmetric hydroamination of an alkoxyallene with the chiral ligand L*, and ring-closing metathesis. The stereochemical integrity of the labile N,O-acetal was conserved in all catalytic transformations.

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