Benjamin L. Kohn, Naoko Ichiishi and Prof. Elizabeth R. Jarvo Silver-Catalyzed Allenylation and Enantioselective Propargylation Reactions of Ketones Angewandte Chemie International Edition 52
More than a silver lining: Certain silver complexes are capable of selective catalysis of either allenylation or asymmetric propargylation reactions of ketones. Ligand-free conditions lead to allenyl alcohols as the major product, whereas ligation with Walphos-8 gives enantioenriched homopropargyl alcohols. This method can be applied to reactions of prochiral diarylketones to provide optically enriched tertiary diaryl alcohols.
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