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Wenbin Wu, Xin Li, Huicai Huang, Xiaoqian Yuan, Junzhu Lu, Kailong Zhu and Prof. Dr. Jinxing Ye Asymmetric Intramolecular Oxa-Michael Reactions of Cyclohexadienones Catalyzed by a Primary Amine Salt Angewandte Chemie International Edition 52

Version of Record online: 20 DEC 2012 | DOI: 10.1002/anie.201206977

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Michael brings the rings: An asymmetric intramolecular oxa-Michael reaction involving iminium activation has been developed. This reaction provides enantioenriched 1,4-dioxane derivatives with up to 99 % yield and 98 % ee. The method allows for concise and stereoselective access to stereodiverse, complex tetracyclic compounds containing a bicyclo[2.2.2]octan-2-one backbone with multiple chiral centers.

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