Daniel H. Scharf, Pranatchareeya Chankhamjon, Dr. Kirstin Scherlach, Dr. Thorsten Heinekamp, Dr. Martin Roth, Prof. Dr. Axel A. Brakhage and Prof. Dr. Christian Hertweck Cover Picture: Epidithiol Formation by an Unprecedented Twin Carbon–Sulfur Lyase in the Gliotoxin Pathway (Angew. Chem. Int. Ed. 40/2012) Angewandte Chemie International Edition 51
The pathogenic fungus Aspergillus fumigatus produces the infamous toxin, gliotoxin. In their Communication on page 10064 ff., C. Hertweck and co-workers elucidate a key step in the biosynthesis of the transannular disulfide bridge that is indispensable for the deleterious effects of gliotoxin. A single enzyme, GliI, is capable of concomitantly cleaving two CS bonds in a bis(cysteinyl) adduct, to yield a dithiol, ammonia, and pyruvate. Electron micrograph kindly provided by J. Schmaler-Ripcke, Jena.
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