Dr. C. Anders Olson, Jeff Nie, Jonathan Diep, Dr. Ibrahim Al-Shyoukh, Prof. Terry T. Takahashi, Dr. Laith Q. Al-Mawsawi, Jennifer M. Bolin, Angela L. Elwell, Scott Swanson, Dr. Ron Stewart, Prof. James A. Thomson, Prof. H. Tom Soh, Prof. Richard W. Roberts and Prof. Ren Sun Single-Round, Multiplexed Antibody Mimetic Design through mRNA Display Angewandte Chemie International Edition 51
Article first published online: 4 NOV 2012 | DOI: 10.1002/anie.201207005
In a single round: By combining the high-efficiency enrichment through the continuous-flow magnetic separation (CFMS) technique with the analytical power of next-generation sequencing, the generation of antibody mimetics with a single round of mRNA display is made possible. This approach eliminates iterative selection cycles and provides a path to fully automated ligand generation (see picture).
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