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Lorine Brülisauer, Nadia Kathriner, Mark Prenrecaj, Dr. Marc A. Gauthier and Prof. Dr. Jean-Christophe Leroux Tracking the Bioreduction of Disulfide-Containing Cationic Dendrimers Angewandte Chemie International Edition 51

Version of Record online: 5 NOV 2012 | DOI: 10.1002/anie.201207070

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Disulfides enhance the transfection efficacy and reduce the toxicity of cationic gene delivery polymers. A quantitative analysis is provided of the bioreduction of a dynamic bioreducible dendritic polycationic probe in four cell lines. Such knowledge is indispensible for understanding and optimizing bioreducible drug and gene delivery systems.

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