Dr. Mehran Nikan, Dr. Marco Di Antonio, Dr. Keren Abecassis, Dr. Keith McLuckie and Prof. Shankar Balasubramanian An Acetylene-Bridged 6,8-Purine Dimer as a Fluorescent Switch-On Probe for Parallel G-Quadruplexes Angewandte Chemie International Edition 52
Lighting up: The systematic design and synthesis of a G-quartet-inspired fluorescence probe (APD), which is made of two acetylene-bridged purines, are reported. The APD lights up in the presence of parallel DNA (e.g. c-MYC) or RNA G-quadruplexes, while it shows no fluorescence enhancement with double-stranded DNA, antiparallel or mixed-type (e.g. h-Telo) G-quadruplexes (see picture). The utility of APD in the preferential staining of G-quadruplexes is also demonstrated.
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