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Dr. Simonetta Geninatti Crich, Diego Alberti, Ibolya Szabo, Prof. Silvio Aime and Dr. Kristina Djanashvili MRI Visualization of Melanoma Cells by Targeting Overexpressed Sialic Acid with a GdIII-dota-en-pba Imaging Reporter Angewandte Chemie International Edition 52

Article first published online: 6 DEC 2012 | DOI: 10.1002/anie.201207131

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By design: The novel MRI reporter GdIII-dota-en-pba (see picture) selectively binds to sialic acid residues, which are overexpressed on tumors. This imaging reporter accumulates in a murine melanoma B16-F10 mice xenograft and from the MRI signal intensity it is possible to quantify the sialic acid concentration that is directly associated with tumor malignancy.

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