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Dr. Suresh Reddy Chidipudi, Imtiaz Khan and Dr. Hon Wai Lam Functionalization of C sp 3[BOND]H and C sp 2[BOND]H Bonds: Synthesis of Spiroindenes by Enolate-Directed Ruthenium-Catalyzed Oxidative Annulation of Alkynes with 2-Aryl-1,3-dicarbonyl Compounds Angewandte Chemie International Edition 51

Version of Record online: 24 OCT 2012 | DOI: 10.1002/anie.201207170

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Ru(de) awakening: The synthesis of carbocycles by the ruthenium-catalyzed oxidative annulation of alkynes with 2-aryl cyclic 1,3-dicarbonyl substrates is described. Proceeding by the functionalization of Cmath image[BOND]H and Cmath image[BOND]H bonds, and the formation of an all-carbon quaternary center, the reaction provides a diverse range of spiroindenes in good yields with high levels of regioselectivity.

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