E-mail a Wiley Online Library Link

Fuxu Zhan and Prof. Guangxin Liang Formation of Enehydrazine Intermediates through Coupling of Phenylhydrazines with Vinyl Halides: Entry into the Fischer Indole Synthesis Angewandte Chemie International Edition 52

Version of Record online: 6 DEC 2012 | DOI: 10.1002/anie.201207173

Thumbnail image of graphical abstract

Cut to the chase: Direct formation of an enehydrazine, an intermediate in the classic Fischer indole synthesis, solves the regioselectivity problem associated with indolization. This approach not only achieves selective synthesis of indoles through proper selection of the vinyl halide, but also leads to quick construction of desoxyeseroline and esermethole, as well as the key structural motif in the Akuammiline alkaloid vincorine.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field