Nikolas Huwyler and Prof. Dr. Erick M. Carreira Total Synthesis and Stereochemical Revision of the Chlorinated Sesquiterpene (±)-Gomerone C Angewandte Chemie International Edition 51
Revised: The total synthesis of gomerone C results in revision of the stereochemical assignment at C3 (see scheme). The synthetic strategy relies on a late-stage Conia-ene reaction, which efficiently forms the bicyclo[3.2.1]octane containing the bridgehead chloride and generates an exocyclic olefin, which can be used as a flexible handle for further elaboration. The two contiguous quaternary centers are installed by means of a Diels–Alder reaction.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf