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Dr. Nils-Alexander Lakomek, Joshua D. Kaufman, Dr. Stephen J. Stahl, Dr. John M. Louis, Dr. Alexander Grishaev, Dr. Paul T. Wingfield and Dr. Ad Bax Internal Dynamics of the Homotrimeric HIV-1 Viral Coat Protein gp41 on Multiple Time Scales Angewandte Chemie International Edition 52

Version of Record online: 28 FEB 2013 | DOI: 10.1002/anie.201207266

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Always on the move: Solution NMR spectroscopy revealed a high degree of intrinsic mobility for the homotrimeric viral coat protein gp41: a prehairpin intermediate (left) may sample a range of relative orientations of the C-terminal and N-terminal heptad repeats, possibly in exchange with a low population of the late-fusion six-helical bundle (right; FP: fusion peptide, TM: transmembrane helix).

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