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Dr. Simon Harrisson, Dr. Julien Nicolas, Dr. Andrei Maksimenko, Duc Trung Bui, Julie Mougin and Prof. Patrick Couvreur Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization Angewandte Chemie International Edition 52

Version of Record online: 17 DEC 2012 | DOI: 10.1002/anie.201207297

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Magic rubber bullets: Novel anticancer nanoparticles made of well-defined polymer–drug conjugate amphiphiles are prepared by the controlled growth of a hydrophobic polyisoprene chain from a drug macroinitiator by using nitroxide-mediated polymerization (NMP; see picture). The resulting conjugates self-assembled into nanoparticles exhibiting high drug payloads and significant anticancer activities both in vitro and in vivo.

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