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Dr. Jean-Louis H. A. Duprey, Dr. Yusuke Takezawa and Prof. Dr. Mitsuhiko Shionoya Metal-Locked DNA Three-Way Junction Angewandte Chemie International Edition 52

Version of Record online: 13 DEC 2012 | DOI: 10.1002/anie.201207338

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Three-way split: A postsynthetic click reaction has resulted in the conjugation of three bipyridine ligands at the core of a DNA three-way junction structure (see picture). Melting curve analyses revealed that NiII ions significantly stabilize the junction structure through the formation of a [Ni(bpy)3]2+ complex which cross-links three strands. The metal complex shows a diastereomeric preference, thus indicating a chirality transfer from the DNA.

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