Dr. Jiangtao Zhu, Gavin C. Tsui and Prof. Dr. Mark Lautens Rhodium-Catalyzed Enantioselective Nucleophilic Fluorination: Ring Opening of Oxabicyclic Alkenes Angewandte Chemie International Edition 51
Done with 'F'lair: Enantioselective fluorination was achieved by RhI-catalyzed ring opening of oxabicyclic alkenes using Et3N⋅3 HF. The chiral fluorinated scaffolds were obtained under mild reaction conditions in standard glass vessels, and served as useful building blocks for various chiral fluorinated targets. cod=cycloocta-1,5-diene, ppf=phenylphosphinoferrocene, THF=tetrahydrofuran.
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