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Gastón A. Crespo, Majid Ghahraman Afshar and Prof. Eric Bakker Reversible Sensing of the Anticoagulant Heparin with Protamine Permselective Membranes Angewandte Chemie International Edition 51

Version of Record online: 4 NOV 2012 | DOI: 10.1002/anie.201207444

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A permselective membrane electrode allows the rapid and operationally reversible detection of the polycationic polypeptide protamine in physiological samples. Anticoagulant levels of heparin can be measured in undiluted whole blood by adding a known excess of its antidote protamine to discrete blood samples.

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