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Ry R. Forseth, Dr. Saori Amaike, Daniel Schwenk, Katharyn J. Affeldt, Prof. Dr. Dirk Hoffmeister, Prof. Dr. Frank C. Schroeder and Prof. Dr. Nancy P. Keller Homologous NRPS-like Gene Clusters Mediate Redundant Small-Molecule Biosynthesis in Aspergillus flavus Angewandte Chemie International Edition 52

Article first published online: 20 DEC 2012 | DOI: 10.1002/anie.201207456

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Biosynthetic crosstalk: Most gene clusters in fungi are orphans with no known associated metabolites. NMR-based comparative metabolomics was used to identify the products of two highly homologous orphan clusters in Aspergillus flavus. The two clusters encode partially redundant biosynthetic pathways that produce overlapping sets of novel fungal alkaloids, feature NRPS-like genes with unusual functions, and regulate fungal development.

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