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Caroline Aldag, Markus J. Bröcker, Michael J. Hohn, Laure Prat, Gifty Hammond, Abigail Plummer and Dieter Söll Rewiring Translation for Elongation Factor Tu-Dependent Selenocysteine Incorporation Angewandte Chemie International Edition 52

Article first published online: 27 NOV 2012 | DOI: 10.1002/anie.201207567

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Enjoying UTu in concert: A synthetic tRNA (tRNAUTu) was used as a substrate for three E. coli proteins: seryl-tRNA synthetase (SerRS) forming Ser-tRNAUTu, selenocysteine (Sec) synthase (SelA) generating Sec-tRNAUTu, and EF-Tu for Sec-tRNAUTu transport to the ribosome (see scheme). tRNAUTu can be used by the ribosome, thus allowing site-specific Sec insertion into proteins, including formate dehydrogenase H, selenoglutaredoxin, and glutathione peroxidase.

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