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Dr. Jianfeng Li, Dr. Suwei Dong, Dr. Steven D. Townsend, Dr. Thomas Dean, Prof. Thomas J. Gardella and Prof. Samuel J. Danishefsky Chemistry as an Expanding Resource in Protein Science: Fully Synthetic and Fully Active Human Parathyroid Hormone-Related Protein (1–141) Angewandte Chemie International Edition 51

Version of Record online: 4 NOV 2012 | DOI: 10.1002/anie.201207603

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The convergent synthesis of human parathyroid hormone-related protein (hPTHrP, see scheme) has been accomplished through iterative peptide ligations followed by global metal-free dethiylation. The biological activity of synthetic PTHrP has been demonstrated.

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