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Dr. Carlo Fasting, Prof. Christoph A. Schalley, Dr. Marcus Weber, Prof. Oliver Seitz, Prof. Stefan Hecht, Prof. Beate Koksch, Dr. Jens Dernedde, Prof. Christina Graf, Prof. Ernst-Walter Knapp and Prof. Rainer Haag Cover Picture: Multivalency as a Chemical Organization and Action Principle (Angew. Chem. Int. Ed. 42/2012) Angewandte Chemie International Edition 51

Version of Record online: 10 OCT 2012 | DOI: 10.1002/anie.201207626

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Multivalent binding of dendritic polyglycerolsulfate (dPGS) to the surface-exposed adhesion receptor L-selectin shields white blood cells from contacting activated vascular endothelium. In the case of overwhelming inflammation, dPGS treatment strongly inhibits leukocyte emigration and thus acts as a highly effective anti-inflammatory compound. Further information on the topic of multivalency can be found in the Review by R. Haag et al. on page 10472 ff. The cover picture was designed by Dipl.-Chem. Achim Wiedekind, with the background based on a graphic from Juan Gaertner/shutterstock.com.

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