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Matthew Jenner, Sarah Frank, Annette Kampa, Christoph Kohlhaas, Petra Pöplau, Dr. Geoff S. Briggs, Prof. Dr. Jörn Piel and Dr. Neil J. Oldham Substrate Specificity in Ketosynthase Domains from trans-AT Polyketide Synthases Angewandte Chemie International Edition 52

Article first published online: 4 DEC 2012 | DOI: 10.1002/anie.201207690

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Branching out: The substrate specificity profiles for a range of ketosynthase (KS) domains from trans-AT PKSs are reported. Evidence is provided that a sterically demanding amino acid residue adjacent to the active-site Cys residue confers specificity towards non-β-methyl-branched substrates (see scheme).

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