E-mail a Wiley Online Library Link

Matthew Jenner, Sarah Frank, Annette Kampa, Christoph Kohlhaas, Petra Pöplau, Dr. Geoff S. Briggs, Prof. Dr. Jörn Piel and Dr. Neil J. Oldham Substrate Specificity in Ketosynthase Domains from trans-AT Polyketide Synthases Angewandte Chemie International Edition 52

Version of Record online: 4 DEC 2012 | DOI: 10.1002/anie.201207690

Thumbnail image of graphical abstract

Branching out: The substrate specificity profiles for a range of ketosynthase (KS) domains from trans-AT PKSs are reported. Evidence is provided that a sterically demanding amino acid residue adjacent to the active-site Cys residue confers specificity towards non-β-methyl-branched substrates (see scheme).

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field