Yuncong Chen, Chengcheng Zhu, Zhenghao Yang, Junjie Chen, Yafeng He, Yang Jiao, Prof. Weijiang He, Lin Qiu, Jiajie Cen and Prof. Zijian Guo A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria Angewandte Chemie International Edition 52
Quick: An exogenously induced quick increase of the H2S concentration (80 s) in MCF-7 cells can be visualized by ratiometric imaging using a new probe (CouMC) that can target mitochondria. CouMC was constructed by combining merocyanine and coumarin fluorophores. The selective nucleophilic addition of HS− to the merocyanine derivative at neutral pH is crucial for the rapid H2S detection.
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