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Yuncong Chen, Chengcheng Zhu, Zhenghao Yang, Junjie Chen, Yafeng He, Yang Jiao, Prof. Weijiang He, Lin Qiu, Jiajie Cen and Prof. Zijian Guo A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria Angewandte Chemie International Edition 52

Article first published online: 3 JAN 2013 | DOI: 10.1002/anie.201207701

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Quick: An exogenously induced quick increase of the H2S concentration (80 s) in MCF-7 cells can be visualized by ratiometric imaging using a new probe (CouMC) that can target mitochondria. CouMC was constructed by combining merocyanine and coumarin fluorophores. The selective nucleophilic addition of HS to the merocyanine derivative at neutral pH is crucial for the rapid H2S detection.

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