Dr. Gang Li, Dr. Dasheng Leow, Li Wan and Prof. Dr. Jin-Quan Yu Ether-Directed ortho-C–H Olefination with a Palladium(II)/Monoprotected Amino Acid Catalyst Angewandte Chemie International Edition 52
Weak coordination is powerful! A PdII-catalyzed olefination of ortho-CH bonds of arenes directed by weakly coordinating ethers is developed by using monoprotected amino acid (MPAA) ligands. This finding provides a method for chemically modifying ethers, which are abundant in natural products and drug molecules. HFIP=hexafluoroisopropanol.
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