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Wouter W. Kallemeijn, Kah-Yee Li, Dr. Martin D. Witte, André R. A. Marques, Dr. Jan Aten, Saskia Scheij, Jianbing Jiang, Lianne I. Willems, Tineke M. Voorn-Brouwer, Cindy P. A. A. van Roomen, Roelof Ottenhoff, Dr. Rolf G. Boot, Hans van den Elst, Marthe T. C. Walvoort, Dr. Bogdan I. Florea, Dr. Jeroen D. C. Codée, Prof. Dr. Gijsbert A. van der Marel, Prof. Dr. Johannes M. F. G. Aerts and Prof. Dr. Herman S. Overkleeft Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining β-Exoglucosidases In Situ and In Vivo Angewandte Chemie International Edition 51

Version of Record online: 8 NOV 2012 | DOI: 10.1002/anie.201207771

Thumbnail image of graphical abstract

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational isomers of the cyclophellitol aziridine core may give activity-based probes targeting other retaining glycosidase families.

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