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Prof. Dr. Manfred T. Reetz The Importance of Additive and Non-Additive Mutational Effects in Protein Engineering Angewandte Chemie International Edition 52

Article first published online: 4 FEB 2013 | DOI: 10.1002/anie.201207842

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Additive or non-additive, that is the question: The increasing awareness of non-additive cooperative mutational effects in protein engineering is currently providing new theoretical and practical insights. In particular, the directed evolution of stereoselective enzymes as catalysts in organic chemistry and biotechnology profits from this intriguing development.

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