Prof. Barry M. Trost, David A. Thaisrivongs and Etienne J. Donckele Palladium-Catalyzed Enantioselective Allylic Alkylations through C–H Activation Angewandte Chemie International Edition 52
A new ligand class: The title reaction was made possible by the discovery of a new class of phosphoramidite ligands. A variety of sterically and electronically diverse allylarenes undergo reaction with 2-acetyl-1-tetralones to form quaternary carbon stereocenters. This is a conceptually and mechanistically distinct strategy from traditional methods for the synthesis of enantioenriched allylic substitution products. 2,6-DMBQ=2,6-dimethylbenzoquinone.
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