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Dr. Yasunori Minami, Hirofumi Yoshiyasu, Dr. Yoshiaki Nakao and Prof. Dr. Tamejiro Hiyama Highly Chemoselective Carbon[BOND]Carbon σ-Bond Activation: Nickel/Lewis Acid Catalyzed Polyfluoroarylcyanation of Alkynes Angewandte Chemie International Edition 52

Article first published online: 20 NOV 2012 | DOI: 10.1002/anie.201207880

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Selective C[BOND]C bond cleavage: A catalyst consisting of nickel(0)/DPEphos and BPh3 is highly effective for the addition of polyfluorobenzonitriles to alkynes through selective activation of the C[BOND]CN bond over the C[BOND]H or C[BOND]F bonds. The addition reaction is applicable to the sequential insertion of two different alkynes into C[BOND]CN and C[BOND]H bonds (see scheme).

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