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Christiane Wuensch, Johannes Gross, Dr. Georg Steinkellner, Prof. Karl Gruber, Dr. Silvia M. Glueck and Prof. Kurt Faber Asymmetric Enzymatic Hydration of Hydroxystyrene Derivatives Angewandte Chemie International Edition 52

Version of Record online: 17 JAN 2013 | DOI: 10.1002/anie.201207916

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More than one activity: Owing to their hydratase activity, phenolic acid decarboxylases catalyze the regio- and stereoselective addition of H2O across the C[DOUBLE BOND]C double bond of hydroxystyrene derivatives yielding (S)-4-(1-hydroxyethyl)phenols with up to 82 % conversion and 71 % ee. Based on structure analysis and molecular docking simulations, a catalytic mechanism for this novel enzymatic reaction is proposed.

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