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Thomas Zengeya, Dr. Pankaj Gupta and Dr. Eriks Rozners Triple-Helical Recognition of RNA Using 2-Aminopyridine-Modified PNA at Physiologically Relevant Conditions Angewandte Chemie International Edition 51

Article first published online: 4 NOV 2012 | DOI: 10.1002/anie.201207925

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Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases form stable and sequence-selective triple helices with double-stranded RNA at physiologically relevant conditions. The M-modified PNA showed unique RNA selectivity by having two orders of magnitude higher affinity for the double-stranded RNAs than for the same DNA sequences.

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