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Chuan He, Jie Ke, Huan Xu and Prof. Aiwen Lei Synergistic Catalysis in the Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation Angewandte Chemie International Edition 52

Version of Record online: 20 DEC 2012 | DOI: 10.1002/anie.201207970

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Rate-limiting: The transmetalation step of the Sonogashira coupling reaction has been established as the rate-limiting step. This cross-coupling has been demonstrated to be a Pd-catalyzed and Cu-catalyzed synergistic process, which exhibits a first-order kinetic dependence on both the [Pd] and [Cu] catalysts (see scheme).

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