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Dr. Yanyan Li, Eva Luxenburger and Prof. Dr. Rolf Müller An Alternative Isovaleryl CoA Biosynthetic Pathway Involving a Previously Unknown 3-Methylglutaconyl CoA Decarboxylase Angewandte Chemie International Edition 52

Version of Record online: 6 DEC 2012 | DOI: 10.1002/anie.201207984

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Take a detour: An alternative pathway to synthesize isovaleryl coenzyme A (CoA) has recently been suggested in myxobacteria, which is highly active when leucine is limited. Each enzymatic step of this unprecedented route has now been characterized and a novel 3-methylglutaconyl CoA decarboxylase identified that has apparently evolved from CoA transferases.

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