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Dr. Munish Chanana, Dr. Pilar Rivera_Gil, Prof. Dr. Miguel A. Correa-Duarte, Prof. Dr. Luis M. Liz-Marzán and Prof. Dr. Wolfgang J. Parak Physicochemical Properties of Protein-Coated Gold Nanoparticles in Biological Fluids and Cells before and after Proteolytic Digestion Angewandte Chemie International Edition 52

Article first published online: 7 MAR 2013 | DOI: 10.1002/anie.201208019

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What's going on in there?! Little is known about the fate of nanoparticles (NPs) after their internalization by cells and organisms. Protein-coated gold NPs were used to study the physicochemical properties of NPs in extra- and intracellular fluids. These potential vehicles for enzymatic drug delivery were highly stable at pH 7.4 in the presence of salts and free proteins, but agglomerated reversibly under acidic conditions (see picture).

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