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Cam-Van T. Vo, Gediminas Mikutis and Prof. Dr. Jeffrey W. Bode SnAP Reagents for the Transformation of Aldehydes into Substituted Thiomorpholines—An Alternative to Cross-Coupling with Saturated Heterocycles Angewandte Chemie International Edition 52

Article first published online: 23 DEC 2012 | DOI: 10.1002/anie.201208064

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It's a SnAP! The transformation of aldehydes into N-unsubstituted 3-thiomorpholines provides a convenient alternative to metal-catalyzed cross-coupling reactions, which are generally unsuited to the functionalization of saturated N-heterocycles. A copper-mediated radical cyclization is the key to the mild conditions, high functional group tolerance, and broad substrate scope offered by these reagents.

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