E-mail a Wiley Online Library Link

Anton N. Tkachenko, Dr. Pavel K. Mykhailiuk, Dr. Sergii Afonin, Dr. Dmytro S. Radchenko, Vladimir S. Kubyshkin, Prof. Anne S. Ulrich and Prof. Igor V. Komarov A 19F NMR Label to Substitute Polar Amino Acids in Peptides: A CF3-Substituted Analogue of Serine and Threonine Angewandte Chemie International Edition 52

Version of Record online: 12 DEC 2012 | DOI: 10.1002/anie.201208069

Thumbnail image of graphical abstract

Rigid & polar: The cyclobutane scaffold was used to design the first polar nonperturbing rigid CF3-substituted amino acid (left in picture) suitable for replacing the serine/threonine residues in peptides. This amino acid imitates the geometry, structure, and function of serine and threonine, but in contrast to those, it can be used in structural studies of membrane-active Ser/Thr-containing peptides by solid-state 19F NMR spectroscopy.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field